| Gent til 1/8-finaler (vandt 5-3 på straffe) | |
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| 16.02.2023 | Qarabag - Gent 1-0 | | 23.02.2023 | Gent - Qarabag 1-0 |
| 78. | 1-0 | Leandro Andrade | | 74. | 1-0 | Gift Orban |
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| 16.02.2023 | Trabzonspor - FC Basel 1-0 | | 23.02.2023 | FC Basel - Trabzonspor 2-0 |
| 65. | 1-0 | Jens Stryger Larsen  | | 13. | 1-0 | Zeki Amdouni |
| | | | | 77. | 2-0 | Andi Zeqiri |
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| 16.02.2023 | Bodø/Glimt - Lech 0-0 | | 23.02.2023 | Lech - Bodø/Glimt 1-0 |
| | | | | 63. | 1-0 | Mikael Ishak |
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| Fiorentina til 1/8-finaler | |
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| 16.02.2023 | Braga - Fiorentina 0-4 | | 23.02.2023 | Fiorentina - Braga 3-2 |
| 45. | 0-1 | Luka Jovic | | 17. | 0-1 | Andre Castro |
| 55. |  | Vitor Tormena, Braga | | 35. | 0-2 | Alvaro Djalo |
| 60. | 0-2 | Luka Jovic | | 37. | 1-2 | Rolando Mandragora |
| 79. | 0-3 | Arthur Cabral | | 58. | 2-2 | Riccardo Saponara |
| 90. | 0-4 | Arthur Cabral | | 83. | 3-2 | Arthur Cabral |
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| 16.02.2023 | Lazio - CFR Cluj 1-0 | | 23.02.2023 | CFR Cluj - Lazio 0-0 |
| 15. | | Patric, Lazio | | 77. |  | Karlo Muhar, CFR Cluj |
| 45. | 1-0 | Ciro Immobile | | | | |
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| AEK Larnaca til 1/8-finaler | |
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| 16.02.2023 | AEK Larnaca - Dnipro-1 1-0 | | 23.02.2023 | Dnupro-1 - AEK Larnaca 0-0 |
| 84. | 1-0 | Angel Garcia | | | | |
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| 16.02.2023 | Sheriff - Partizan Beograd 0-1 | | 23.02.2023 | Partizan Beograd - Sheriff 1-3 |
| 45. | 0-1 | Ricardo Gomes | | 13. | 1-0 | Queensy Menig |
| 50. | | Igor Vujacic, Partizan Beograd | | 22. | 1-1 | Cedric Badolo, straffe |
| | | | | 45. | 1-2 | Mouhamed Diop |
| | | | | 47. | 1-3 | Mouhamed Diop |
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| Anderlecht til 1/8-finaler (vandt 3-0 på straffe) | |
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| 16.02.2023 | Ludogorets - Anderlecht 1-0 | | 23.02.2023 | Anderlecht - Ludogorets 2-1 |
| 9. | 1-0 | Thiago Rodrigues | | 13. | 1-0 | Selvmål, Franco Russo |
| | | | | 68. | 2-0 | Yari Verschaeren |
| | | | | 71. | 2-1 | Thiago Rodrigues |
| | | | | 97. | | Jakub Piotrowski, Ludogorets |
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Forside